
They contain granules that can secrete other proteins required for creating a firm plug to seal blood vessel breaks. They contain proteins on their surface that allow them to stick to breaks in the blood vessel wall and also to stick to each other. But even though platelets are merely cell fragments, they contain many structures that are critical to stop bleeding. Platelets are actually not true cells but merely circulating fragments of cells. The dominant hormone controlling megakaryocyte development is thrombopoietin (often abbreviated as TPO). As megakaryocytes develop into giant cells, they undergo a process of fragmentation that results in the release of over 1,000 platelets per megakaryocyte. Platelets are produced from very large bone marrow cells called megakaryocytes. Platelets are produced in the bone marrow, the same as the red cells and most of the white blood cells. There are several different types of white cells but all are related to immunity and fighting infection.

There are only 5,000 to 10,000 white blood cells per microliter.

The principal function of platelets is to prevent bleeding. The normal platelet count is 150,000-350,000 per microliter of blood, but since platelets are so small, they make up just a tiny fraction of the blood volume. Platelets are only about 20% of the diameter of red blood cells.Platelets are the smallest of the three major types of blood cells. In this section we introduce platelets themselves.
